University of Fukui b University of Fukui, Faculty of Medical Sciences b University of Fukui Hospital (Japanese)
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  Hidehiko Okazawa, MD, PhD
  Director, Professor, Medical Imaging Division
     
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Functional imaging using methods for molecular imaging; Kinetic modeling using PET; Activation studies with O-15 water or fMRI
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The research target of the Division of Biomedical Imaging is to generate, analyze and translate various functional in vivo images using positron emission tomography (PET), MRI and other modalities of medical imaging devices. Kinetic modeling with physiological analysis and applying molecular imaging methods to clinical studies are good examples of our research target. Brain activation studies using fMRI are also a major subject of our research interest.

Publications: http://www.med.u-fukui.ac.jp/birc/staff/HO_pub.html

 
  Yasushi Kiyono, PhD
  Professor, Molecular Imaging Division
     
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Development and evaluation of new molecular imaging probes for PET
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My interest is in visualizing the changes in our body non-invasively using molecular imaging probes. I have been developing new molecular imaging probes to image cardiac sympathetic nervous function and noradrenergic nervous function in the brain. Now I am starting to develop new tumor imaging probes and probes for internal radiation therapy.
 
  Tetsuya Tsujikawa, MD, PhD
  Associate Professor, Medical ImagingDivision
     
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Development and clinical application of new PET probes
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A lot of molecular imaging is PET which can visualize function of receptors and enzymes, and expression of protein / amino acid etc. I engage in basic and clinical evaluation including kinetic analysis of new PET probes targeting neuropsychiatric disorders and malignant tumors.
 
 
 
  Tetsuya Mori, PhD
  Assistant Professor, Radiopharmaceutical Chemistry Division
     
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I am engaged in the research on radiopharmaceutical chemistry: synthesis, in vitro and in vivo evaluation of novel molecular probes for PET imaging. In addition, I am trying to develop an original automatic synthesis module. I am also involved in the production and quality control of radiopharmaceuticals for clinical PET studies.
 
 
  Akira Makino , PhD
  Assistant Professor, Molecular Imaging Division
     
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Development and evaluation of new molecular imaging probes for PET
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New molecular imaging probes, which utilize specific characters of the targeted diseases, will be developed. Molecular probe candidate compounds combined with the features of various modalities such as PET, SPECT, MRI, and near-infrared fluorescence (NIRF), will be created making full use of synthetic chemistry techniques. By cyclical consideration of molecular design, chemical synthesis, and biological evaluation of the candidate compounds, I am trying to develop a probe which leads to the establishment of a new diagnostic method.
 
 
  Koji Shimada, PhD
  Senior Assistant Professor, Functional Neuroimaging Division
     
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Identification of development-dependent structural and functional changes in human brain using magnetic resonance imaging (MRI) techniques.
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My research interest focuses on the structural and functional plasticity associated with development (and learning) of linguistic and communicative skills. Ifm trying to elucidate what changes in the brain, how the brain changes, or when these changes occur during development (and learning). Additional focus is individual differences in the brain basis of linguistic and communicative skills (including developmental disorders).
 
 
  Martinez Miguel Ernesto, PhD.
  Specially-appointed Assistant Professor, PhD
     
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Development of F-18 radiopharmaceutical for PET imaging of infections.
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Development of more efficient and less time-consuming reactions to synthesize new PET radiotracers is a challenge for radiochemists due to the short half-lives of positron-emitting radioisotopes. Aminosugars labeled with positron-emitting radioisotopes have been investigated for the in-vivo evaluation of biochemical processes in cancerous tissue. Since aminosugars are obligatory structural components of many biologically important macromolecules including glycoproteins and polysaccharides, they could also be used for imaging infection using PET. The aim of my research is to develop aminosugar labeled compounds which will contribute to progress in PET imaging of infections.
 
 
   
     
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 Panasonic Medicalengineering Collaborative Division
 
 
  Harumi Ito, MD, PhD
  Distinguished Professor
     
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  Masaki Kiyono, MS
  Invited Professor
     
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  Toyohiko Sakai, MD
  Lecturer, Department of Radiology
     
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 Research Collaborators (Univ. Fukui)
 
 
  Tatsuya Asai, PhD
  Associate Professor, Image Engineering Divsion (Associate Professor, Faculty of Engneering)
     
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The functions of various ion channels, water channels (aquaporin), transporters on the neuronal excitation and the signal transmission at synapses.
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After moving to the newly-established Department of Nuclear Power and Energy Safety Engineering, I have been collaborating with researchers at the Biomedical Imaging Research Center. I would like to combine the molecular imaging technique using position nucleotides with the optical imaging technique to exploit new research areas.
 
  Yuji Tokunaga, PhD
  Professor, Faculty of Engneering (Molecular Imaging Division)
     
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1. Design and synthesis of smart molecules aiming at biomedical and pharmaceutical applications
2. Development of artificial receptor for molecular sensors
3. Synthesis and application of rotaxanes
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Our Lab provides a quite valuable opportunity for young researchers and graduate students who want to work in the fields of organic chemistry and supramolecular chemistry. See: http://www.matse.fukui-u.ac.jp/~tokunaga/

see: http://www.matse.fukui-u.ac.jp/~tokunaga/
 
 
 
 
   
     
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 Students & Post-doctoral Fellow
 
 
  Rikiya Maruyama, RT
  Graduate Student Faculty of Medical Sciences , PhD Course
     
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  Tasmiah Rahman, MD.
  Graduate Student Faculty of Medical Sciences, PhD Course
     
  Œค‹†ƒe[ƒ}
Medical Imaging, Clinical Research
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  Muhammad M. Islam, MS.
  Graduate Student Faculty of Medical Sciences, PhD Course
     
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Basic Research
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  Kunieda M
  Master course Student (Department of Engineering)
     
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  Manabe T, Murata M
  Master course Student (Department of Engineering)
     
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 Research Collaborators (Other Institutes)
 
 
  Yukie Yoshii, PhD
  Visiting Researcher ,National Institute of Radiological Sciences
     
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Metabolic analysis of protist and animal cells - How have mitochondria evolved? -
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I have studied on evolution of protosynthesis in eukaryotes in University of Tsukuba until 2004 June and then moved to BIRC, University of Fukui. I am interested in evolution of eukaryotes and their symbiotic evolution. My recent research subject is metabolic analysis of ptotist and animal cells and the evolutionary implication.
 
 
  Masato Kobayashi, PhD
  Assistant Professorr, Kanazawa University
     
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Brain functional imaging using PET 
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 SecretaryEResearch Assistant
 
  Junko Nakamura
  Secretary
     
   
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  Yumiko Kurokawa
  Research Technician
     
   
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PET reception, RI management, Clinical study assistance
Birth Place: Hikone, Shiga, Japan
Hobby: Driving, Puzzles
 
  Miyuki Yabu
  Research Technician
     
   
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  Hiroshi Oikawa
  Research Technologist
     
   
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  Yuki Okamoto
  Secretary
     
   
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  Etsuko Mizuguchi
  Secretary
     
   
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  Akira Ito
  CMI. Inc.
     
   
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 Visiting Professors
 
  Norihiro Sadato, MD, PhD
  Visiting Professor, Functional Neuroimaging Division (Professor, NIPS, co-appointed)
     
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Sadato Laboratory http://www.nips.ac.jp/fmritms/english/index.html
 
  Makoto Yoneda, MD, PhD
  Visiting Professor, Fukui Prefectural University
     
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  Takako Furukawa, PhD
  Visiting Professor, Molecular Imaging Division (Team Leader, NIRS)
     
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The rapid advance in molecular and cellar biology has brought us ever growing knowledge of molecular events underlying physiological and pathological changes in our body and enabled new types of therapy directly targeting the molecular events. My interest is in visualizing the changes in our body non-invasively using radiolabeled probes at the molecular level, typically as the changes in gene expression, to realize the quicker and more accurate diagnosis and to choose effective therapy protocols, as well as to further deepen our understanding of the mechanisms supporting our life.
 
  Keiichi Kawai, PhD
  Visiting Professor, Radiopharmaceutical Chemistry Division (Professor, Kanazawa Univ.)
     
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Design and Evaluation of New Radiopharmaceuticals for Functional Diagnosis and Tumor Therapy, Pharmacokinetic Regulation
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The main purpose of my research is the development of novel radiopharmaceuticals for noninvasive imaging of physiological and/or biochemical function. I have been designed and evaluated new radiolabeled compounds, mainly metabolic substrate derivatives, in order to visualize metabolic and neuronal function using molecular imaging approaches. The development of tumor imaging and therapeutic agents are also approved. I am investigating pharmacokinetic regulation methods by DDS technique.
 
  Kazutaka Yamamoto MD, PhD
  Visiting Professor, Oncology Division (Associate Professor, Shool of Medicine)
     
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  Tatsuo Ido, PhD
  Visiting Professor, Molecular Imaging Division
     
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 Past Directors
 
  Yasuhisa Fujibayashi, PhD, DMedSci
  Director (2006.4 - 2010.3) Emeritus Professor
     
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Recent progress in molecular biology brings us a new insight of diseases, namely abnormality of gene expression. Our focus is to develop molecular probes which allow us to visualize disease-related gene expression non-invasively. Present target organs are brain, heart and tumors. Internal radiation therapy agent labeled with beta emitting nuclide is also under development.

 
  Yoshiharu Yonekura, MD, PhD
  (1998.4 - 2006.3) Emeritus Professor
     
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  Yasushi Ishii, MD, PhD
  (1994.5 - 1998.3) Emeritus Professor
     
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University of Fukui Biomedical Imaging Research Center
  23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui Prefecture, 910-1193, Japan
TelF0776-61-3111@EmailFbircfukui@gmail.com
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